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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e01666abc3a00d1dafaeea2e177d290779a53ec4ae594c49bf0d6f337f498c5' 
  AND token = 'P5PxzHyz15OGExwefyaVGJMnmJ8JbPH0c7MTAeaDCwk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}