SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22c9182927724ce357263280df8c88ab05b6e6c84e2975124db17216191c30a6' 
  AND token = 'iRLxysqsMc8SadwCW59VhON9O34uzuFKVKiFMmkWjoA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}