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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd107d16051e42aad55a1e291a419d1781983050801705852d5da6ad3a3010318' 
  AND token = 'avnttWpo10X2rPSQ0Twsd6AwN4IJWAzUVvmtW2j3OFw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}