SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e386b8e3b1e661ada90e196daa200fc390c8b92203223e3d2987c6d7135d0bc1' 
  AND token = 'DGyC/5ADUAYXvCqbTUTR7EkUhISU0FuuE2YKVPBkSOc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00048

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}