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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e33eca25089798037b7ca309d3883a72788309e4b2047b1c3753f0aa368d25a9' 
  AND token = 'w7BfBREOCRfry4V2JdjDuOZVm36xMsvnW+ug1OKR2Jk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}