SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0769ca21678448c46f8bb3b34bd5d7008c9c68fcf691d04e7f6d5ea8c306a654' 
  AND token = '0PHy+pg2aYDOTsQY8n2YhEWMVG2WSuBRYYQ1y3UMibI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}