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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd68c108178f4877216ed05483dd325d4f9b7d9197c2cd21864105e7f930424ec' 
  AND token = 'xKoZHE+8BCiTPBJykr2+v8O55WbmwvzZY9oQ6Xxxs8A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}