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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8fb498dd0829adcaa7551ccf2cd059359be7f730c6e4c329e50b3ae1a04cf387' 
  AND token = 'ryq8CAKBYLtvc3W6GAa+QD6gKu+GDp45vTMvc9D1iQs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}