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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1143f5fe6778db440e5ac77086a6b918dec6de73d8c2eb412c8a0a678f1d8723' 
  AND token = 'fBkMBDOMOe8QVWaFUV2hQeMeqpPJRvkC0qDyUL3+s6g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}