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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '537f3234bd597f2d51b9a374f1f0a1abb3ed9e8018cac17f1e51231d9e8f731f' 
  AND token = '6nGIa1QvKtiT/L54GqyeYj1X45ruJ4pTWh8oBF5yBcc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}