SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'bc6be5b2840772803b6d229b39d46a34ae5a2a5aa45b9d7290b3672aed75a382' 
  AND token = 'YV8EPDfqCaHqVIHR2l0RbR1Hxwg4EcLM5VLMOgBCt28=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}