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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '485139f7a3c82a45ccfdf186a2c5c666f006c8fb3b8d116c16b666ab48de23a2' 
  AND token = 'n0y5GPXYmKZwNcLLvg4dL4E+1BsFlPoT20ppXxlH0ds=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}