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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65f2eb6f9954e6e9012e2a7f3decb8cff26c21008443e938553fdb4bd6bfb38a' 
  AND token = 'GC7h8LwteKUFkLedGSxe05JB/cAHV0DjSUgzJ9Nsyz4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}