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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1d254460c78b78f8913faba431f8a763609c25aa1ecfe9d6da6fe26f40493423' 
  AND token = 'tR3OWjqn+ykmwoSUowpkBmzyNwN0CD/jHG6RP8cl3MQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}