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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c0b5a0a6d2921fac821a759a2be212a1d22d90b60bdf397b2cc4f7726be57fa4' 
  AND token = 'VJmwVxsD4wxexGiaVVDaaPQV2vFAyhP4PR9AmI4GUaQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}