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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0278aa9a1f90571d16dd5a1abdf6532c2181cf3e5a57f52466b211d4cb6d7980' 
  AND token = 'yTwP25r3PuRjD9kHMSWIPvF+KZyKHbPrhQFBtQX+0RE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}