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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ce1fb69095e52647433d06aeb6ee4338316e3ea33d0b57a50566137031ddb1e5' 
  AND token = 'iO3Qpyh6U9wkDrAJikfELl6n5QrFDjUF3/ZkVZsdso0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}