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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e525c431a2a5038210a5dba0b07bc3900dd0afd6d47f50a0557a1ec6b9265639' 
  AND token = '9aX3y/avqq7W10CD7114s53hTEAhMEri65+4TIM1SAs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}