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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52529c3fb5cf78a062d92651d86e3f0ad890814fb63b024267631965939f3eb1' 
  AND token = 'N+HAmWYjc3OP9xTw8we3pSSgM7r0BBkMvWIP6FDHwSM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}