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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e2a8d9eeb91bb3066a3750318c9434edf198f49b70e44685f2b7ec3050040b5b' 
  AND token = '+k2D5AfB9m+EnW2gGMWsrsQTteeX9fXMwxZDok0Hqh8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}