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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e7d72f5cfd0be82cfe1378705750daca0654ba1018af2d1500dd1fecc1876884' 
  AND token = '/x1C2IjGB3mtnqBA6E/syAS2ma456YBdTELaTLuRUJU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}