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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8d43d1e890e5704c7d3a4271b4da74363c866512cc1ce12f918542da3539d6f9' 
  AND token = 'eqizFKkapK1sz7I6wVcP304xrR/0AxP+389VA2xRM/M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}