SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81a0e2354d64328571f61bd89e99bb5581f6fa52ab5dc0801a007a1e2e28cc24' 
  AND token = 'EUs1deyUdeUWsZ/OrfTPHLTBtlLwZgBZ0ba2lh1mZNY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00050

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}