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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e8c28325dbfc62127c7bd36ef57a50d03eea0789ab4de3f7c00679767d4d354b' 
  AND token = 'yzMt5pFsZqLd+MJaVEmRUECXb+4UQy0PRNQWIy+IygA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}