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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4df101f275dd2d4155467159bb409354f04c1fb22e4ff1923f331b633ee3599d' 
  AND token = '7xZ8N1QkxMTi2PL5fY+6TDc1CGmBj0LsdPPvXx/Cq+k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}