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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25291d82848c1a1f5c0bfe62f5860a69099eb99ea1425412a1e3b86d6b6d8e45' 
  AND token = 'pDq102NmBuo0xkhQN+btbz8AlXLmzMBtB0ZkHFxjDzE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}