SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd8484af7a1b1244824220dd1135ac3b030769965368a495dea935df2dc4a1ead' 
  AND token = 'IpAk7+eZOSqogYv6vhDuEihiZ32x3EXmM6mRFYSD0Q0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}