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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f21e16a19a430875543dc56fedb30251dc4876114b07ebec38b160f5f43004fc' 
  AND token = 'sF+DIpBE9roLT1e4iiHN/L+kW1Wd5PGdSC59zCKsRTc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}