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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '44e7f6cd8eb61b8e299307e33d3ab779353498f4b1ec554590e04534fed6e236' 
  AND token = 'DQaKg9NLRPytaEGRvno42/EKJYYrVJdNGVi03mrc0XM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}