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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'df86a3778ce2f5312e35152fc4360c7adba4a3e9b106d16cc2115b8d1f28bc1a' 
  AND token = 'DHTTvkg/gQg1q6GbeXPKhiUNayrmDrMjefIY6MTYz3I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}