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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'dc39fac22fe392023f7187d2f5d0ec528de4374b1dc651f070df1b8bb7dc1024' 
  AND token = 'xP1nIqc/x//P8F8KLXtaxyNrJrFdBPo4IpyzFnPA6m4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}