SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22506e3dbdf81787d035d773ec6ec1fbdab6095aead0d7fa5020ee2e4f8f2d48' 
  AND token = 'KWd3Yr7NTcEscCDZN40MMLZ7YeVg2hOOx/ULRcc+M04=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}