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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5001780fb7b628062405ee7a7287ac52519c3653087bd8c1e0750e539f361096' 
  AND token = '+PE82N3HuxmV/k/YTcd6uvOEZfIvTSGp9z5Avz8Qw1w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}