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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '397b61b15c5fc5e0903ecc7d2f1707918952c7ca17576802b2e58df64dfd6700' 
  AND token = '8RO9vdGs+B+TPNbwADEUCaVS4G3SZIZQYq7Ja7x0cdg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}