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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b221bb454465c8c6f905c1455816a2c76fa6995094b4375c9dd84621a9fdf9a' 
  AND token = 'eK/N1akwiFpICu8jVpFiS6pAteEOMmYR94hr2ufFFCU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}