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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '59ffcbedaad172c2d4cb2521d2a0ba5f3344def38a5e44d717daf75e404340d5' 
  AND token = 'vzSL+MQtGLyUR/mgodjK8lH3YxbjRmYbJMpFoD07x7Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}