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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '57e8a6aba588a1c6d108288451cd82d921bd2557a62c1ad3d1c468d147abf54a' 
  AND token = 'NmQc6F8ljA3XWgQaQK/fHHKOz33la9Ad0+Vj5B4E9aA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}