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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1c3a33579f69c7f3b352d05bcd025cc4b5f8eaff71381c57067125a792af1c49' 
  AND token = '/jL9RN1fE+qcKEOFxKENZQDW4Y9iK1vB8SPOzpZPtm4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}