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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7281fa4818f03595b4fec71725c32772c50551e83e60efa1fc04944676454165' 
  AND token = '9njGOJIQ5DhDvYzXETeNS1zB8kfoNImJVf425sDj294=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}