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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5858e2a5f6d926acd6d7d7adc7648ad663d1ec0038d9e1bedccacfc934a56020' 
  AND token = 'uz5BAMjZgfEjYS+UIP/1kDHUlTcKuDUtVdG/lbyA5i4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}