SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45f9ddbcf38803d8ba0e7be7dc1a0437808b71f46b59504e229e0b0b8d13498f' 
  AND token = 'Ep0yNRC8HAQCpqjWqcxipprox1MrQ7xsfGqSu/ToD5Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}