SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b26abbca7b50118f76b1a6654ae70ed531d8e55a380ebdb317ee4f9644fad64a' 
  AND token = 'WuYqDBSDHBmyCZdCfgRY7p9YQ7Y69sdlNb2GoGk9UlU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}