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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '04b81444a0f474f97f28f3570c17f5433c9974f7cb91dc0b644cdf20edf4d8b0' 
  AND token = '+DGapEtoGRFWJjIFw6KUjc2ICD/lYcMkVY7iCaS/tMk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}