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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1894bb330e8f24b04f452082d0628a82b47aa2ede3fab4a8d9526be4c0bbe5a1' 
  AND token = 'eUuM+KlpDuynaFwxsR7PBo7nSefLjDnZHuoCIq3NbPE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}