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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '278727b18b20c361c83d49e4532041f57b41e8e675904c5057bd5bf420b18250' 
  AND token = '10Rsl3ZS+TabApCHSiX5pc8I5+GZjK+ptCHFoNBZS2c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}