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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81214f22ca7571f3509010649bd61903157603e045bbc1601c6a8de015f85392' 
  AND token = 'y5t95GmMayR8UoiYE4FjbUrKgKshQZxW3vUOnr2W9/g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}