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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1a2653d8a51d102fbeb330bc21600dfd14530f93bd9841cb7e743d0f222f3afc' 
  AND token = '2tb+RxF1+DCEY8ko/Dp2FcrBsu4SHEVsPjUkx+RQ1Sw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}