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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50ab4a177063273a1de55450a1983dc41a243942d1ab71be06c5220182c07bee' 
  AND token = 'jkTSKSLCa4QcufTjfBZ6+vH7kWCO73IcJpWGmzBOqOs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}