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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '180d10b42d7dff129e9fc8fba60a4135e5469521d2184fb599cdccc5b77ada43' 
  AND token = '7Hh9Fzisj5ih+e9SJJ+CAp0DxbCkg0vov97oM1kF2mg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}