SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '99e5ecd222b006cd24e696282bad51f66875020a1638960e37a957edfac3ed2c' 
  AND token = 'ZZ3KY+6L7oozvjL3LEKMdAUXASUhmRyfABOQ9kAx1xo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}